News

COVID: Third Dose Vaccination Increases 3-5 Folds To Neutralize Antibody Titers

KUALA LUMPUR, Aug 20 — A third dose of COVID-19 vaccine, given at an interval of six months after the second dose, can lead to a strong boost in immune response, with an increase of three to five folds in neutralising antibody titers.

Pharmaniaga Berhad vaccine specialist Dr Ajit Pal Singh Raina said the results from a recently completed immune-persistence study of Sinovac demonstrated that two doses of CoronaVac COVID-19 vaccine induced good immunogenicity.

He said although neutralising antibody levels declined after six months, a two-dose vaccination schedule generated a strong immune memory.

“Hence, will a booster shot be necessary? The third dose of CoronaVac effectively boosts neutralising titers and provides a better immuno-protection response. This pattern is consistent with other vaccines like AstraZeneca, showing higher concentrations of total Immunoglobulin G (IgG) antibodies after a third dose.

“It is also worth mentioning that timing for a booster dose is critical and not to be given too early,” he was quoted as saying in his article for Thoughts published at Bernama news portal today.

Immunogenicity or neutralising antibody titers is defined as the ability to provoke an immune response capable to kill or neutralise virus causing disease, he said, adding that it would result from the bio-material being detected by the body’s immune system as a foreign object and the body’s response to eliminate it with the use of neutralising antibodies.

Citing the University College London (UCL) researchers, he said decay in Antibody titers would also be seen with other COVID-19 vaccines where antibody levels start declining from as early as six weeks after complete vaccination with Pfizer and AstraZeneca vaccines.

He said the antibody reduced further by more than half in 10 weeks, confirming the need for a booster dose.

The findings were published as a research letter in The Lancet, which are based on data from over 600 vaccines.

“However, different methods and measuring units are used to measure decay at the antibody level, hence, the results are not directly comparable but indicate a similar decline in antibodies overtime for all vaccines.

“After initially spurning the idea of booster dose and complete understanding of how the vaccine works against COVID-19 virus, it is clear from recent studies that protection from severe disease and hospitalisation remain high after vaccination.

“However, the surge in cases caused by the contagious and deadly variants have caused some countries to look more closely at booster shots, and some have even started administering them,” he added.

Sources: BERNAMA

Adib Mohd

Recent Posts

LG’s New MAGNIT Active Micro LED: When Your Living Room Becomes a Luxury Cinema

LG is taking “movie night at home” to the next level. Introducing the LG MAGNIT… Read More

19 minutes ago

The Touch of Fall: Kate Spade’s Loop and Halo Bags Bring Cozy-Chic Energy This Season

Fall isn’t just a season, it’s a mood. And Kate Spade New York is serving… Read More

48 minutes ago

The First 72 Hours After a Stroke, Crucial for Recovery and Saving Lives

Did you know that you could lose approximately 1.9 million neurons after a stroke hit?… Read More

20 hours ago

Huawei ICT Academy Will Level Up Your Digital Mastery

Huawei Technologies (Malaysia) Sdn Bhd (Huawei Malaysia) and Universiti Teknologi MARA (UiTM) Johor are collaborating… Read More

20 hours ago

Malaysia Faces Rising Dementia Care Burden as Families Struggle Alone

Malaysia Faces Rising Dementia Care Burden as Families Struggle Alone Malaysia’s rapidly aging population is… Read More

1 day ago

From Oval Office to Silver Screen: Trump Cameo Legacy You Can Never Recreate

From Oval Office to Silver Screen: Trump Cameo Legacy You Can Never Recreate Imagine you… Read More

1 day ago

This website uses cookies.